{"id":23541,"date":"2024-06-06T10:41:15","date_gmt":"2024-06-06T09:41:15","guid":{"rendered":"https:\/\/www.istegroup.com\/?post_type=product&p=23541"},"modified":"2025-03-14T09:57:18","modified_gmt":"2025-03-14T09:57:18","slug":"les-telomeres","status":"publish","type":"product","link":"https:\/\/www.istegroup.com\/fr\/produit\/les-telomeres\/","title":{"rendered":"Les t\u00e9lom\u00e8res"},"content":{"rendered":"

L\u2019\u00e9volution a dot\u00e9 les organismes eucaryotes de chromosomes lin\u00e9aires, \u00e9quipant chaque chromosome d\u2019extr\u00e9mit\u00e9s qui sont prot\u00e9g\u00e9es par une structure particuli\u00e8re nomm\u00e9e \u00ab t\u00e9lom\u00e8re \u00bb. L\u2019effet consid\u00e9rable des t\u00e9lom\u00e8res sur la stabilit\u00e9 globale du g\u00e9nome et leur implication dans le vieillissement et le cancer ont contribu\u00e9 \u00e0 leur fascination.<\/p>\n

Cet ouvrage pr\u00e9sente les t\u00e9lom\u00e8res en tant qu\u2019exemple de diversit\u00e9 et d\u2019unit\u00e9 du vivant, \u00e0 travers les nombreux mod\u00e8les qui y sont d\u00e9crits (cili\u00e9s, levures, cellules humaines ou mod\u00e8le souris). Dans la premi\u00e8re partie, les auteurs introduisent l\u2019histoire de leur d\u00e9couverte, leurs r\u00f4les biologiques, leurs aspects structuraux (s\u00e9quences, longueur, prot\u00e9ines du complexe shelterine, structures G4 et T-loop, compaction et ancrage) et fonctionnels (r\u00e9plication, transcription, maintien). La seconde partie explore leurs dysfonctionnements, les cons\u00e9quences sur la sant\u00e9 humaine et les approches th\u00e9rapeutiques.<\/p>\n

Les t\u00e9lom\u00e8res<\/em> est r\u00e9dig\u00e9 par des chimistes, biochimistes, structuralistes et biologistes illustrant ainsi l\u2019interdisciplinarit\u00e9 de l\u2019\u00e9tude des t\u00e9lom\u00e8res.<\/p>","protected":false},"excerpt":{"rendered":"

L\u2019\u00e9volution a dot\u00e9 les organismes eucaryotes de chromosomes lin\u00e9aires, \u00e9quipant chaque chromosome d\u2019extr\u00e9mit\u00e9s qui sont prot\u00e9g\u00e9es par une structure particuli\u00e8re nomm\u00e9e \u00ab t\u00e9lom\u00e8re \u00bb. L\u2019effet consid\u00e9rable des t\u00e9lom\u00e8res sur la stabilit\u00e9 globale du g\u00e9nome et leur implication dans le vieillissement et le cancer ont contribu\u00e9 \u00e0 leur fascination. Cet ouvrage pr\u00e9sente les t\u00e9lom\u00e8res en tant […]<\/p>\n","protected":false},"featured_media":56885,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"product_brand":[],"product_cat":[4289],"product_tag":[],"class_list":{"0":"post-23541","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-sciences","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-variable"},"acf":[],"yoast_head":"\nLes t\u00e9lom\u00e8res - ISTE Group<\/title>\n<meta name=\"description\" content=\"Cet ouvrage pr\u00e9sente les t\u00e9lom\u00e8res en tant qu\u2019exemple de diversit\u00e9 et d\u2019unit\u00e9 du vivant, \u00e0 travers les nombreux mod\u00e8les qui y sont d\u00e9crits (cili\u00e9s, levures, cellules humaines ou mod\u00e8le souris).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.istegroup.com\/produit\/les-telomeres\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les t\u00e9lom\u00e8res - ISTE Group\" \/>\n<meta property=\"og:description\" content=\"Cet ouvrage pr\u00e9sente les t\u00e9lom\u00e8res en tant qu\u2019exemple de diversit\u00e9 et d\u2019unit\u00e9 du vivant, \u00e0 travers les nombreux mod\u00e8les qui y sont d\u00e9crits (cili\u00e9s, levures, cellules humaines ou mod\u00e8le souris).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.istegroup.com\/produit\/les-telomeres\/\" \/>\n<meta property=\"og:site_name\" content=\"ISTE Group\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-14T09:57:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.istegroup.com\/wp-content\/uploads\/2019\/11\/Les-telomeres.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"300\" \/>\n\t<meta property=\"og:image:height\" content=\"450\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.istegroup.com\/produit\/les-telomeres\/\",\"url\":\"https:\/\/www.istegroup.com\/produit\/les-telomeres\/\",\"name\":\"Les t\u00e9lom\u00e8res - 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